Akutna plućna insuficijencija; respiratorna depresija, akutna ili hronična teška respiratorna insuficijencija (insuficijencija ventilacije se može pogoršati);Benzodiazepini nisu indikovani kod pacijenata sa teškim oštećenjem funkcije jetre, s obzirom na to da mogu da izazovu nastanak encefalopatije. Kod pacijenata sa hroničnim oboljenjem j
Hepatic Insufficiency Decreases in clearance and protein binding, and raises in volume of distribution and 50 %-everyday living are documented in individuals with cirrhosis. In this kind of sufferers, a two- to 5-fold increase in necessarily mean fifty percent-life has become noted. Delayed elimination has also been documented for that active metab
Before you commence utilizing a medication, you'll want to advise your doctor of any health-related problems or allergic reactions you'll have, any medications you might be using, whether you are pregnant or breast-feeding, and every other substantial facts about your health. These components may well influence how it is best to use this medication
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Dosage should be individualized for max helpful impact. Although the standard daily dosages provided beneath will meet up with the needs of most sufferers, there'll be some who may well need bigger doses. In this sort of situations dosage ought to be enhanced cautiously to avoid adverse results.In the event you encounter any other indications which